Slc17A7 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The SLC17A7 gene (Solute Carrier Family 17 Member 7), also known as VGLUT2 (Vesicular Glutamate Transporter 2), encodes a vesicular glutamate transporter expressed primarily in thalamocortical neurons and subpopulations of cortical and hippocampal neurons.[1] VGLUT2 plays a crucial role in glutamate neurotransmission and has been linked to several neurodegenerative and neurodevelopmental disorders.
| Attribute | Value |
|---|---|
| Gene Symbol | SLC17A7 |
| Full Name | Solute Carrier Family 17 Member 7 |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 8703 |
| Ensembl ID | ENSG00000177508 |
| UniProt ID | Q9P2U8 |
The VGLUT2 protein is a member of the SLC17 anion transporter family and contains 12 transmembrane helices that form the translocation pore.[2] It operates as a proton-dependent symporter that concentrates glutamate in synaptic vesicles.
VGLUT2 exhibits a distinct expression pattern compared to VGLUT1:[3]
The study of Slc17A7 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Fremeau RT, et al. (2001). The identity of the vesicular glutamate transporter. Nature. 410(6830):93-97.
[2] Eriksen J, et al. (2016). Synaptic vesicle glycosylation. Current Opinion in Neurobiology. 39:52-58.
[3] Hisano S, et al. (2000). Two vesicular glutamate transporters in brain. Brain Research Reviews. 33(1):97-107.
[4] Kashani A, et al. (2008). Targeting VGLUT2 in neurodegenerative disease. Neurobiology of Disease. 31(2):217-225.
[5] Tordera RM, et al. (2007). VGLUTs in Parkinson's disease. Experimental Neurology. 207(2):238-247.
[6] Nakashima A, et al. (2018). VGLUT2 mutations in neurodevelopmental disorders. Molecular Psychiatry. 23(8):1775-1783.
[7] van Vliet EA, et al. (2014). Vesicular glutamate transporters in epilepsy. Brain Research. 1567:32-43.