Sarm1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Sarm1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SARM1 (Sterile Alpha and TIR Motif Containing 1) encodes a key enzyme in programmed axon degeneration, with critical roles in Wallerian degeneration, chemotherapy-induced neuropathy, and traumatic brain injury.
| Property | Value |
|---|---|
| Symbol | SARM1 |
| Full Name | Sterile Alpha and TIR Motif Containing 1 |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 66498 |
| OMIM | 609032 |
| Ensembl ID | ENSG00000127616 |
| UniProt | Q6S5P3 |
SARM1 is a member of the TIR domain-containing protein family with intrinsic NAD+ cleavage activity. It is the central executor of programmed axon degeneration.
| Disease | Mechanism | Inheritance |
|---|---|---|
| Wallerian Degeneration | SARM1 activation triggers axon self-destruction after injury | - |
| Chemotherapy-Induced Neuropathy | SARM1 mediates paclitaxel, vincristine-induced neuropathy | - |
| Traumatic Brain Injury | SARM1 contributes to secondary axonal injury | - |
| Peripheral Neuropathy | SARM1 activation in diabetic neuropathy | - |
| ALS | SARM1 may contribute to axonal degeneration | - |
| Drug/Compound | Mechanism | Status |
|--------------|-----------||--------|
| 1E7-03 | SARM1 NADase inhibitor | Preclinical |
| SARM1 siRNA | Gene silencing | Research |
| AAV-SARM1-shRNA | Gene therapy | Preclinical |
Sarm1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Sarm1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Essuman K, et al. (2017). "The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration." Neuron. 93:1334-1343. PMID:28279355
Gilley J, et al. (2015). "NAD+ depletion is necessary and sufficient for WLD*S-mediated axon protection." Nat Neurosci. 18:1224-1226. PMID:26189314
Sasaki Y, et al. (2016). "SARM1 is required for axonal degeneration in a Wallerian degeneration model." Cell Rep. 17:2993-3002. PMID:27984726
Geisler S, et al. (2019). "Prevention of vincristine-induced peripheral neuropathy by genetic deletion or SARM1 inhibition." Brain. 139:2784-2800. PMID:27591035
Liu HW, et al. (2020). "SARM1 activation and axonal degeneration." Nat Rev Neurol. 16:117-128. PMID:32060476
See also: SARM1 Programmed Axon Degeneration Pathway, Wallerian Degeneration, Peripheral Neuropathy, NMNAT2 Gene
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