DNAJB8 is a member of the DnaJ/Hsp40 family of molecular chaperones. It is expressed in stem cells and certain somatic tissues, including the brain, where it plays a role in protein quality control and may protect against age-related protein aggregation diseases. [1]
DNAJB8 (DnaJ Heat Shock Protein Family Member B8) is a co-chaperone that works with Hsp70 family proteins to facilitate protein folding, prevent aggregation, and target misfolded proteins for degradation. It is part of the cellular protein quality control machinery that becomes increasingly important in age-related neurodegenerative diseases. [2]
| Property | Value |
|---|---|
| Gene Symbol | DNAJB8 |
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member B8 |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 165727 |
| OMIM ID | — |
| Ensembl ID | ENSG00000179421 |
| UniProt ID | Q8N5M4 |
| Encoded Protein | DNAJB8 protein |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, protein aggregation disorders |
DNAJB8 is a J-domain containing co-chaperone:
DNAJB8 has restricted tissue expression:
In the brain:
Gene Expression: Human brain expression data from Allen Brain Atlas shows DNAJB8 is expressed across multiple brain regions with highest expression in cerebral cortex and hippocampus. Expression patterns are consistent with its role in testis-specific chaperone, neuronal expression.
Single-Cell Expression: Single-cell RNA-seq data from the Allen Brain Cell Atlas shows DNAJB8 expression across major brain cell types, with enrichment in neurons and astrocytes.
External Resources:
Data Source: Allen Human Brain Atlas, Human Middle Temporal Gyrus (MTG) dataset.