KAT7 (Lysine Acetyltransferase 7), also known as HBO1 or MYST2, is a histone acetyltransferase primarily involved in histone H4 acetylation, particularly at H4K5, H4K8, and H4K12. KAT7 plays important roles in DNA replication, transcription, and cell cycle progression.
| Property |
Value |
| Gene Symbol |
KAT7 |
| Gene Name |
Lysine Acetyltransferase 7 |
| Aliases |
HBO1, MYST2 |
| Chromosomal Location |
17q21.33 |
| NCBI Gene ID |
11143 |
| OMIM |
609593 |
| UniProt |
O95251 |
| Ensembl |
ENSG00000136541 |
KAT7/HBO1 is a member of the MYST family:
- Histone H4 acetylation (primary)
- Also acetylates H3
- acetyltransferase activity requires complex formation
KAT7 functions in the HBO1 complex:
- HBO1 (KAT7) - catalytic subunit
- ING4/ING5 - reader proteins
- MTA1 or MTA2 - co-factors
KAT7 is essential for DNA replication:
- Regulates replication origin firing
- Required for replication fork progression
- Cell cycle-dependent activity
Regulates gene expression:
- Transcriptional activation
- Elongation control
- Chromatin accessibility
Critical for cell proliferation:
- S-phase progression
- Checkpoint regulation
- Apoptosis control
KAT7 dysregulation in:
- Prostate cancer
- Breast cancer
- Liver cancer
- Ovarian cancer
Potential roles in:
- Neurodegeneration
- Cognitive function
KAT7 is being explored as a therapeutic target:
- HDAC inhibitors
- Small molecule inhibitors
KAT7 (HBO1) is a histone H4 acetyltransferase essential for DNA replication and transcription, with oncogenic potential in several cancers.
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