DLL1 (Delta-Like 1) is a member of the Delta/Serrate/Lag-2 (DSL) family of Notch ligands that functions as a ligand for Notch receptors, playing crucial roles in cell fate determination, neurogenesis, and synaptic plasticity. This gene plays important roles in the nervous system and has been implicated in various aspects of neurodegenerative disease pathogenesis.
| DLL1 Gene | |
|---|---|
| Gene Symbol | DLL1 |
| Full Name | Delta-Like 1 |
| Chromosomal Location | 6q27 |
| NCBI Gene ID | 28514 |
| OMIM | 604552 |
| Ensembl ID | ENSG00000198719 |
| UniProt ID | O00548 |
| Associated Diseases | Alzheimer's Disease, Neurodevelopmental Disorders, Cancer |
DLL1 encodes Delta-like protein 1, a transmembrane ligand for Notch receptors. DLL1 is a member of the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL1-Notch signaling is a highly conserved pathway critical for cell fate determination, embryonic development, and tissue homeostasis. In the nervous system, DLL1 plays essential roles in neurogenesis, neuronal differentiation, synaptic plasticity, and neural stem cell maintenance.
| Disease | Role | Mechanism |
|---|---|---|
| Alzheimer's Disease | Modifier | DLL1-Notch signaling affects amyloid processing and neurogenesis |
| Neurodevelopmental Disorders | Risk Factor | Altered DLL1 disrupts neural circuit formation |
| Cancer | Oncogene/Tumor Suppressor | Context-dependent role in tumor progression |
DLL1 expression is altered in Alzheimer's disease brains, and the DLL1-Notch pathway interacts with amyloid-beta to regulate neuronal survival and neurogenesis.
DLL1 is expressed in:
The protein localizes to: