| IL17A | |
|---|---|
| Full Name | Interleukin 17A |
| Chromosome | 6p12.2 |
| NCBI Gene ID | 3605 |
| Ensembl ID | ENSG00000112116 |
| OMIM ID | 603250 |
| UniProt ID | Q16552 |
| Associated Diseases | Autoimmune encephalitis |
IL17A (Interleukin 17A) is a gene involved in neuronal survival, development, and function. The gene is located on chromosome 6p12.2.
IL17A encodes a protein that plays important roles in the nervous system, including neuronal survival, differentiation, and synaptic plasticity.
Mutations or dysregulation of IL17A are associated with several neurological disorders:
The gene is primarily expressed in:
Further research is needed to identify key publications for this gene.
IL17A (Interleukin-17A) is the founding member of the IL-17 cytokine family. It is primarily produced by Th17 cells, a distinct CD4+ T helper subset, as well as by innate immune cells including gamma-delta T cells, innate lymphoid cells type 3 (ILC3s), and neutrophils. IL-17A is a potent pro-inflammatory cytokine that plays critical roles in host defense against extracellular bacteria and fungi, but is also central to the pathogenesis of autoimmune diseases.
IL-17A signals through:
IL-17A in AD:
Il17a knockout mice:
| Drug | Target | Indication |
|---|---|---|
| Secukinumab | IL-17A | Psoriasis, PsA, AS |
| Ixekizumab | IL-17A | Psoriasis |
| Bimekizumab | IL-17A/F | Psoriasis |
IL-17A is a potent pro-inflammatory cytokine central to autoimmune disease and host defense. In neurodegeneration, it promotes neuroinflammation and neuronal damage. IL-17A blockade is effective in psoriasis and autoimmune diseases, with potential for neurodegenerative conditions.
The study of Il17A — Interleukin 17A has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.