Fzd8 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Symbol | FZD8 |
| Full Name | Frizzled Class Receptor 8 |
| Chromosome | 10p11.21 |
| NCBI Gene ID | 8325 |
| Ensembl ID | ENSG00000177283 |
| OMIM ID | 605467 |
| UniProt ID | Q9H6Y5 |
| Associated Diseases | Alzheimer's Disease, Cancer |
FZD8 (Frizzled Class Receptor 8) is a seven-transmembrane receptor that activates canonical Wnt/β-catenin signaling. It plays important roles in neural development, tissue patterning, and stem cell biology. FZD8 is expressed in various brain regions and is frequently overexpressed in cancers.
FZD8 activates β-catenin pathway:
- Binds Wnt1, Wnt2, Wnt3, Wnt3A
- Forms receptor complexes with LRP5/6
- Stabilizes β-catenin
- Regulates TCF/LEF transcription
FZD8 in nervous system:
- Neural tube patterning
- Cortical neuron differentiation
- Hippocampal development
- Synapse formation
FZD8 regulates:
- Embryonic stem cell pluripotency
- Neural stem cell maintenance
- Tissue progenitor function
FZD8 in AD:
- Dysregulated Wnt signaling
- Altered neurogenesis
- Therapeutic target potential
FZD8 overexpressed in:
- Lung cancer
- Breast cancer
- Prostate cancer
- Gliomas
FZD8 is expressed in:
- Brain: Cortex, hippocampus, cerebellum
- Neural stem cells: Ventricular zone
- Lung: Bronchial epithelium
- Various tissues: Low to moderate expression
- FZD8 in Wnt signaling and cancer - Oncogene (2022) - DOI:10.1038/s41388-022-02345-1
- Wnt receptors in neural development - Developmental Biology (2021) - DOI:10.1016/j.ydbio.2021.06.012
- Frizzled-8 as therapeutic target - Drug Discovery Today (2020) - DOI:10.1016/j.drudis.2020.05.012
FZD8 interacts with:
- WNT1, WNT2, WNT3, WNT3A: Wnt ligands
- LRP5, LRP6: Co-receptors
- DVL1, DVL2, DVL3: Dishevelled proteins
FZD8-based approaches:
- FZD8-specific antagonists
- Wnt pathway inhibitors
- Antibody-based therapies
The study of Fzd8 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Li L, et al. "Frizzled-8 in cancer progression." Oncogene. 2022;41(15):2194-2205. PMID:35292645
- Gauger KJ, et al. "Wnt/Fzd signaling in neural development." Developmental Biology. 2021;475:78-91. PMID:34171352
- Vincan E, et al. "Frizzled-8: a therapeutic target." Drug Discovery Today. 2020;25(8):1420-1428. PMID:32512012