Cathepsin E (CTSE) is an aspartic protease belonging to the pepsin superfamily. Unlike other cathepsins, CTSE is primarily expressed in immune cells and gastrointestinal tract. It plays roles in antigen processing, immune regulation, and may contribute to amyloid-beta degradation in Alzheimer's disease.
CTSE (Cathepsin E) is a gene located on chromosome 1q31 that plays an important role in neurodegenerative disease. Mutations in CTSE are associated with Alzheimer's Disease, Parkinson's Disease, Autoimmune Disorders. The gene is catalogued as NCBI Gene ID 1519 and OMIM 131100.
The CTSE gene encodes a protein involved in key neuronal functions. It is expressed in Stomach, Intestines, Immune cells, Brain (low expression).
Expression data is available from the Allen Human Brain Atlas.
CTSE mutations are linked to the following conditions:
Alzheimer's Disease, Parkinson's Disease, Autoimmune Disorders