| Symbol | STAT4 |
| Full Name | signal transducer and activator of transcription 4 |
| Chromosome | 2q32.2 |
| NCBI Gene ID | 6755 |
| OMIM | 600556 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q14765 |
| Associated Diseases | Autoimmune diseases, RA, SLE, Sjögren's syndrome |
Signal transducer and activator of transcription 4 (STAT4) is a transcription factor activated by IL-12, IL-23, and type I interferons. It is essential for Th1 and Th17 cell differentiation and function. STAT4 regulates genes involved in inflammation, cell proliferation, and apoptosis. In the nervous system, STAT4 is involved in neuroinflammation and autoimmune responses. Polymorphisms in STAT4 are associated with increased risk of autoimmune diseases including rheumatoid arthritis and systemic lupus erythematosus.
Expressed in immune cells (T cells, NK cells, monocytes). Low expression in other tissues including brain. In CNS, primarily expressed in microglia and infiltrating immune cells.
The STAT4 gene is associated with the following neurodegenerative and neurological conditions:
Autoimmune diseases, RA, SLE, Sjögren's syndrome
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.