Senp2 — Sumo Specific Peptidase 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| SENP2 Protein | |
|---|---|
| Protein Name | SUMO-specific protease 2 |
| Gene Symbol | SENP2 |
| NCBI Gene ID | 59343 |
| UniProt ID | Q9Y2W1 |
| MW | 68 kDa |
| Subcellular Location | Nucleus (Nuclear pore), Cytoplasm |
SENP2 (SUMO-specific protease 2) is a nuclear envelope-associated SUMO protease that plays critical roles in regulating nucleocytoplasmic transport, nuclear pore complex (NPC) function, and various signaling pathways[1]. Unlike SENP1 which has broad substrate specificity, SENP2 has more specific roles in processing SUMO-2/3 chains and regulating nuclear envelope proteins[2]. SENP2 dysfunction has been implicated in neurodegenerative diseases, cancer, and cardiovascular disorders.
SENP2 has distinct substrate preferences:
SENP2 is uniquely positioned to regulate NPC function[3]:
The study of Senp2 — Sumo Specific Peptidase 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Hickey CM, et al. (2012). Regulation of SNArE complexes and SUMOylation. Biochimica et Biophysica Acta. 1813: 2122-2128. ↩︎
Gong L, et al. (2010). Structure of SENP2 in complex with SUMO-chains. Journal of Molecular Biology. 400: 473-487. ↩︎
Wu J, et al. (2009). SENP2 is a nuclear envelope-associated SUMO protease. Journal of Biological Chemistry. 284: 12005-12014. ↩︎
Luo J, et al. (2012). SUMOylation at the crossroads of autophagy and neurodegeneration. Journal of Molecular Neuroscience. 48: 177-183. ↩︎
Stade K, et al. (2002). A quantitative RanGTPase map of the nuclear envelope. Developmental Cell. 2: 753-767. ↩︎