Timm13 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Timm13 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TIMM13 (Translocase of Inner Mitochondrial Membrane Subunit 13) is a small mitochondrial intermembrane space protein that functions as part of the small TIM chaperone complex. Together with TIMM8A, TIMM8B, TIMM9, and TIMM10, it facilitates the import of hydrophobic proteins across the mitochondrial intermembrane space.
| Attribute | Value |
|---|---|
| Gene Symbol | TIMM13 |
| Full Name | Translocase of Inner Mitochondrial Membrane Subunit 13 |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 10430 |
| OMIM | 607497 |
| Ensembl ID | ENSG00000120437 |
| UniProt ID | Q9Y2H5 |
TIMM13 is a key component of the small TIM chaperone complex that guides proteins across the mitochondrial intermembrane space. The TIM8/13 complex specifically facilitates the import of hydrophobic inner membrane proteins.
High expression in:
| Approach | Status | Description |
|---|---|---|
| Mitochondrial Biogenesis | Research | PGC-1α activators upregulate TIMM13 |
| Antioxidant Therapy | Experimental | CoQ10, MitoQ for mitochondrial protection |
| Protein Import Enhancers | Preclinical | Small molecules targeting TIM complex |
Koehler CM, et al. (1998). "A novel protein complex involved in protein import into mitochondria." Proc Natl Acad Sci USA. PMID:9671742
Herrmann JM, et al. (2013). "Biogenesis of the mitochondrial intermembrane space." Biochim Biophys Acta. PMID:23603797
Chacinska A, et al. (2005). "Minimal machinery for mitochondrial protein import." EMBO J. PMID:15667445
Neupert W, Herrmann JM. (2007). "Translocation of proteins into mitochondria." Annu Rev Biochem. PMID:17406338
Milenkovic D, et al. (2009). "Biogenesis of mitochondrial proteins." Adv Exp Med Biol. PMID:19242698
Timm13 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Timm13 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.