| IL13 | |
|---|---|
| Full Name | Interleukin 13 |
| Chromosome | 5q31.1 |
| NCBI Gene ID | 3605 |
| Ensembl ID | ENSG00000169194 |
| OMIM ID | 147683 |
| UniProt ID | P08960 |
| Associated Diseases | Neuroinflammation |
IL13 (Interleukin 13) is a gene involved in neuronal survival, development, and function. The gene is located on chromosome 5q31.1.
IL13 encodes a protein that plays important roles in the nervous system, including neuronal survival, differentiation, and synaptic plasticity.
Mutations or dysregulation of IL13 are associated with several neurological disorders:
The gene is primarily expressed in:
Further research is needed to identify key publications for this gene.
IL13 (Interleukin-13) is a cytokine produced primarily by activated T helper 2 (Th2) cells, basophils, and eosinophils. It shares many functional similarities with IL-4 and plays a central role in Th2-mediated immune responses, allergic inflammation, and tissue remodeling. In the nervous system, IL-13 contributes to neuroinflammation and modulates glial cell function.
IL-13 signals through:
IL-13 in AD:
IL-13 is a Th2 cytokine with important roles in allergy and tissue remodeling. Its effects in the CNS are complex, promoting M2 microglial activation which may be beneficial in neurodegeneration. Therapeutic modulation shows promise for autoimmune and allergic diseases.
The study of Il13 — Interleukin 13 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.