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| Symbol | GUCY1A1 |
| Full Name | Guanylate Cyclase 1 Soluble Subunit Alpha 1 |
| Chromosome | 4q31.3 |
| NCBI Gene | 2982 |
| OMIM | 139396 |
| Ensembl | ENSG00000147854 |
| UniProt | Q02108 |
| Associated Diseases | Cerebral autosomal dominant arteriopathy, hypertension |
The GUCY1A1 gene (Guanylate Cyclase 1 Soluble Subunit Alpha 1) encodes the alpha subunit of soluble guanylate cyclase, which produces cGMP in response to nitric oxide (NO). This enzyme is important for vascular tone, neurovascular coupling, and intracellular signaling in the brain.
GUCY1A1 (Guanylate Cyclase 1 Alpha 1) is a subunit of soluble guanylate cyclase, an enzyme that produces cyclic GMP (cGMP) from GTP. Guanylate cyclase plays important roles in nitric oxide signaling, vasodilation, and neuronal function. The NO-cGMP pathway is implicated in synaptic plasticity, memory formation, and neurodegeneration.
GUCY1A1 encodes the alpha subunit of soluble guanylate cyclase, which produces cGMP in response to NO. Important for vascular tone and neurovascular coupling.
Expressed in vascular endothelium and brain.