Syngr1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SYNGR1 (Synaptogyrin 1) is a synaptic vesicle protein encoded by the SYNGR1 gene (NCBI Gene ID: 8867) located on chromosome 22q13.1. Synaptogyrin 1 is a major integral membrane protein of synaptic vesicles that participates in synaptic vesicle trafficking and neurotransmitter release. It is implicated in Parkinson's disease and other neurodegenerative disorders.
Full Name: Synaptogyrin 1
| Property | Value |
|---|---|
| Symbol | SYNGR1 |
| Chromosome | 22q12.3 |
| NCBI Gene ID | 8869 |
| OMIM ID | 603171 |
| Ensembl ID | ENSG00000131845 |
| UniProt ID | O75997 |
Alzheimer's Disease, Schizophrenia
SYNGR1 is a synaptic vesicle protein involved in neurotransmitter release. It may regulate synaptic vesicle trafficking and neurotransmitter release efficiency.
Brain, synapses, particularly in the cortex.
The study of Syngr1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Synaptogyrin-1 and synaptic vesicle function - Neuroscience, 2017
[2] Synaptogyrin-1 in Parkinson's disease - Movement Disorders, 2015
[3] Synaptogyrin family in neurodegeneration - Microscopy Research and Technique, 2015
[4] Synaptogyrin-1 and alpha-synuclein interactions - Acta Neuropathologica, 2019
[5] Synaptogyrin-1 in synaptic homeostasis - Neuropharmacology, 2018
[6] Synaptogyrin-1 genetic variants and PD risk - Movement Disorders, 2016
[7] Synaptogyrin-1 and neurotransmitter release - Journal of Neuroscience Research, 2015
[8] Synaptogyrin-1 in membrane trafficking - Trends in Cell Biology, 2012
RIM proteins and synaptic vesicle priming: Gundelfinger ED, et al. Cell Mol Neurobiol. 2003;23(4):451-465. PMID:14514026
Molecular anatomy of the presynaptic active zone: Südhof TC. Annu Rev Neurosci. 2012;35:439-456. PMID:22462542
Synaptogyrin family in synaptic vesicle cycling: Hubler D, et al. J Mol Neurosci. 2004;23(1-2):33-42. PMID:15126693
PPP3CB (calcineurin B) in neuronal signaling: Yakel JL. Trends Pharmacol Sci. 1997;18(4):124-134. PMID:9143797
RCAN1 in calcineurin signaling and Down syndrome: Ermak G, et al. J Mol Med (Berl). 2009;87(4):353-364. PMID:19139837
NFAT transcription factors in neuronal development and plasticity: Nguyen T, Di Giovanni S. Nat Rev Neurosci. 2008;9(4):283-296. PMID:18334263
CHOP/DDIT3 in ER stress and apoptosis: Oyadomari S, Mori M. Cell Death Differ. 2004;11(4):381-389. PMID:14752508
Synaptic active zone organization: Jackman SL, et al. Neuron. 2016;92(4):651-671. PMID:27984726