EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) is a critical subunit of the eukaryotic translation elongation factor 1 (EF-1) complex, which is essential for protein synthesis in all eukaryotic cells. The EF-1 complex mediates the delivery of aminoacyl-tRNAs to the ribosome during the elongation phase of translation, making it fundamental for cellular protein homeostasis.
| Symbol | EEF1G |
|---|---|
| Full Name | Eukaryotic Translation Elongation Factor 1 Gamma |
| Aliases | EF-1γ, EF1G |
| Chromosomal Location | Chr11q12.3 |
| NCBI Gene ID | 1939 |
| Ensembl ID | ENSG00000185208 |
| UniProt ID | P26641 |
| Associated Diseases | ALS, Alzheimer's Disease, Parkinson's Disease, Neurodegeneration, Cancer |
The EF-1 complex consists of five subunits[1]:
EEF1G plays several essential roles in translation[2]:
Emerging research indicates EEF1G has additional cellular functions[3]:
EEF1G has been strongly implicated in ALS pathogenesis[4][5]:
In Alzheimer's disease, EEF1G dysfunction contributes to[6]:
EEF1G alterations in PD include[7]:
EEF1G (P26641) is a 437 amino acid protein with:
EEF1G is considered a potential therapeutic target in ALS[8]:
Paradoxically, EEF1G is overexpressed in various cancers, highlighting its importance in cell proliferation and survival[9].
Understanding EEF1G function provides opportunities for therapeutic intervention:
Andersen GR, Nissen P, Nyborg J. Elongation factors in protein biosynthesis. Trends in Biochemical Sciences. 2003. ↩︎
Negrutskii BS, El'skaya AV. Eukaryotic translation elongation factor 1 alpha: structure, expression, functions, and possible role in aminoacyl-tRNA channeling. Progress in Nucleic Acid Research. 1998. ↩︎
Ejiri S. The moonlighting function of translation elongation factor EF-1 alpha in ribosomal aggregation and association with the cell surface. Indian Journal of Biochemistry & Biophysics. 2002. ↩︎
Chen YZ, Bennett CL, Huynh HM, et al. DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). American Journal of Human Genetics. 2004. ↩︎
dropiewska J, Hausmanowa-Petrusewicz I. The involvement of translation elongation factors in ALS. Neurologia Neurochirurgia Polska. 2015. ↩︎
Ma T, Klann E. Amyloid beta: linking synaptic plasticity deficits to memory impairments in Alzheimer's disease. Neurobiology of Learning and Memory. 2012. ↩︎
Liu Z, Li H, Hu J, et al. Dysregulation of translation and protein homeostasis in neurodegenerative diseases. Translational Neurodegeneration. 2020. ↩︎
Kim SH, Deng L, Ur Rahman M, et al. Targeting stress granules in amyotrophic lateral sclerosis and frontotemporal dementia. Trends in Pharmacological Sciences. 2020. ↩︎
Edmunds T, Nagamani S, Grimes AM, et al. Overexpression of translation elongation factor-1 gamma in tumors. Oncology Reports. 2002. ↩︎