DAPK1 encodes a calcium/calmodulin-dependent serine/threonine kinase that promotes apoptosis and autophagy. It plays important roles in neurodegeneration and has been implicated in Alzheimer's disease, Parkinson's disease, and stroke.
DAPK1 (Death-Associated Protein Kinase 1) is a pro-apoptotic kinase that responds to various cell death signals. It is highly expressed in the brain and regulates neuronal cell death pathways in response to injury and disease processes.
| Property | Value |
|---|---|
| Gene Symbol | DAPK1 |
| Full Name | Death-Associated Protein Kinase 1 |
| Chromosomal Location | 9p21.3 |
| NCBI Gene ID | 1612 |
| OMIM | 600730 |
| Ensembl ID | ENSG00000196730 |
| UniProt ID | P53355 |
| Encoded Protein | DAPK1 protein |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, stroke, cancer |
DAPK1 is a calcium/calmodulin-dependent serine/threonine kinase.
Key normal physiological functions include:
The study of Dapk1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.