| SLC11A2 — Solute Carrier Family 11 Member 2 | |
|---|---|
| Symbol | SLC11A2 |
| Full Name | Solute Carrier Family 11 Member 2 (Divalent Metal Transporter 1, DMT1) |
| Chromosome | 12q13.12 |
| NCBI Gene | 4891 |
| Ensembl | ENSG00000124317 |
| UniProt | P49281 |
| Diseases | Alzheimer's Disease, Parkinson's Disease |
| Expression | Duodenum, Brain, Kidney, Bone marrow |
SLC11A2 (Solute Carrier Family 11 Member 2), also known as DMT1 (Divalent Metal Transporter 1) or NRAMP2, is a gene located on chromosome 12q13.12 that encodes a proton-coupled divalent metal ion transporter. SLC11A2 is essential for iron homeostasis and is responsible for dietary iron absorption in the intestine and iron transport across the blood-brain barrier[1][2]. Dysregulation of SLC11A2 has been implicated in the pathogenesis of Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders characterized by iron accumulation.
| Property | Value |
|---|---|
| Location | 12q13.12 |
| Protein | DMT1/NRAMP2 (561 aa) |
| Primary function | Divalent metal ion transport |
| Aliases | DMT1, NRAMP2, DCT1 |
SLC11A2/DMT1 is a critical regulator of systemic iron balance:
DMT1 transports multiple divalent metal ions:
DMT1 is expressed in brain endothelial cells and regulates:
DMT1 dysregulation contributes to AD pathogenesis:
DMT1 is strongly implicated in PD:
The study of Slc11A2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388(6641):482-488. PMID:9242408 ↩︎ ↩︎
Wang J, Liu K, Wang X, et al. Divalent metal transporter 1 in the brain: implications for neurodegenerative diseases. Cell Mol Neurobiol. 2010;30(2):233-242. PMID:19672731 ↩︎
Athanasiou Y, Smith L, Huat Y, et al. Divalent metal transporter 1 and brain iron metabolism in Alzheimer's disease. J Alzheimers Dis. 2019;67(2):503-513. PMID:30664182 ↩︎
Jiang L, Wang J, Sun J, et al. Divalent metal transporter 1 regulates iron metabolism in Parkinson's disease. Neurobiol Dis. 2019;130:104535. PMID:31276772 ↩︎