Rad18 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | RAD18 |
|---|---|
| Gene Name | RAD18 E3 Ubiquitin Protein Ligase |
| Chromosome | 9q31.1 |
| NCBI Gene ID | 56852 |
| OMIM ID | 605360 |
| Ensembl ID | ENSG00000028203 |
| UniProt ID | Q9NS91 |
| Associated Diseases | Fanconi Anemia, Cancer, DNA Repair Disorders |
| --- | --- |
| Categories | DNA Repair, Genome Stability |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
RAD18 is an E3 ubiquitin ligase involved in translesion DNA synthesis and DNA damage tolerance. It partners with RAD6 to monoubiquitinate PCNA, which allows lesion bypass by error-prone polymerases. RAD18 also contributes to homologous recombination repair. Dysregulated RAD18 is associated with cancer predisposition and neurological disorders.
The RAD18 gene is associated with several diseases.
The study of Rad18 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.