| IL1A — Interleukin 1 Alpha | |
|---|---|
| Symbol | IL1A |
| Full Name | Interleukin 1 Alpha |
| Chromosome | 2q14.1 |
| NCBI Gene | 3552 |
| Ensembl | ENSG00000136378 |
| OMIM | 147760 |
| UniProt | P01583 |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Rheumatoid Arthritis |
| Expression | Hippocampus, Cerebral cortex, Microglia, Astrocytes |
Il1A — Interleukin 1 Alpha is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
IL1A encodes interleukin-1 alpha, a pro-inflammatory cytokine of the interleukin-1 family. IL1A is located on chromosome 2q14.1 and is expressed in various tissues including the brain. The gene is catalogued as NCBI Gene ID 3552.
IL1A plays a critical role in neuroinflammation, a key pathological feature of neurodegenerative diseases.
IL1A is a potent pro-inflammatory cytokine that:
IL1A signals through:
IL1A polymorphisms have been associated with increased AD risk. Elevated IL1A levels in brain tissue and CSF correlate with disease severity. The cytokine contributes to:
IL1A is elevated in the substantia nigra and CSF of PD patients. It may contribute to:
IL1A promotes demyelination and disease progression in MS models.
The study of Il1A — Interleukin 1 Alpha has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.