TRIM17 is a RBCC family E3 ubiquitin ligase expressed primarily in the brain. It regulates neuronal apoptosis and has been implicated in spinocerebellar ataxia and Huntington's disease through its interaction with mutant huntingtin protein.
| Property | Value |
|---|---|
| Gene Symbol | TRIM17 |
| Gene Name | Tripartite Motif Containing 17 |
| Chromosomal Location | 1q42.13 |
| NCBI Gene ID | 10527 |
| OMIM | 607050 |
| UniProt | Q9C0B1 |
TRIM17 is a RBCC family E3 ubiquitin ligase expressed primarily in the brain. It regulates neuronal apoptosis and has been implicated in spinocerebellar ataxia and Huntington's disease through its interaction with mutant huntingtin protein.
The TRIM17 gene is associated with the following neurodegenerative and related diseases:
TRIM17 expression and its relevance to brain function is under active investigation.