NEIL3 encodes a DNA glycosylase that specializes in repairing oxidized purines, particularly in proliferating cells and neural tissue. It plays important roles in neurogenesis and has been implicated in Alzheimer's disease.
NEIL3 (Nei-like DNA Glycosylase 3) is a DNA repair enzyme belonging to the FPG/Nei family. Unlike other NEIL proteins, NEIL3 is primarily expressed in stem cells and neural tissue, where it plays crucial roles in maintaining genomic integrity during neurogenesis.
| Property | Value |
|---|---|
| Gene Symbol | NEIL3 |
| Full Name | Nei Like DNA Glycosylase 3 |
| Chromosomal Location | 4q34.3 |
| NCBI Gene ID | 55247 |
| OMIM ID | 608773 |
| Ensembl ID | ENSG00000128590 |
| UniProt ID | Q8TCJ1 |
| Encoded Protein | NEIL3 protein |
| Associated Diseases | Alzheimer's disease, ALS, RTTN |
NEIL3 is a DNA glycosylase that recognizes and removes oxidized purines.
Key normal physiological functions include:
The study of Neil3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.