Dctn5 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Gene Symbol: DCTN5
Full Name: Dynactin Subunit 5
Chromosomal Location: 16p12.2
NCBI Gene ID: 25427
OMIM: 610398
Ensembl ID: ENSG00000136830
UniProt ID: Q9Y282
Associated Diseases: Neurological disorders
DCTN5 (Dynactin Subunit 5, also known as p25 or p27) is a subunit of the dynactin complex. It is involved in the dynactin-dynein interaction and contributes to the function of the motor complex in cellular transport. The dynactin complex is essential for dynein-mediated retrograde axonal transport, and defects in this system are implicated in various neurodegenerative diseases.
DCTN5 (also known as p25 or p27) is a subunit of the dynactin complex. It is involved in the dynactin-dynein interaction and contributes to the function of the motor complex in cellular transport.
The dynactin complex is essential for dynein-mediated retrograde axonal transport. Defects cause:
DCTN5 is expressed in various tissues, with expression in brain and neuronal tissues.
The study of Dctn5 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.