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| Symbol | GUCY1B1 |
| Full Name | Guanylate Cyclase 1 Soluble Subunit Beta 1 |
| Chromosome | 4q31.3 |
| NCBI Gene | 2983 |
| OMIM | 139397 |
| Ensembl | ENSG00000147862 |
| UniProt | P21452 |
| Associated Diseases | Cerebral vasculopathy |
The GUCY1B1 gene (Guanylate Cyclase 1 Soluble Subunit Beta 1) encodes the beta subunit of soluble guanylate cyclase, which combines with the alpha subunit to form the functional enzyme that produces cGMP in response to NO.
GUCY1B1 (Guanylate Cyclase 1 Beta 1) is a subunit of soluble guanylate cyclase, an enzyme that produces cyclic GMP (cGMP) from GTP. Guanylate cyclase plays important roles in nitric oxide signaling, vasodilation, and neuronal function. The NO-cGMP pathway is implicated in synaptic plasticity, memory formation, and neurodegeneration.
GUCY1B1 encodes the beta subunit of soluble guanylate cyclase. It partners with GUCY1A1 to form the NO receptor.
Expressed in blood vessels and brain.