Snrnp200 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| | |
|---|---|
| **Gene Symbol** | SNRNP200 |
| **Full Name** | Small Nuclear Ribonucleoprotein 200 |
| **Chromosomal Location** | 2q11.2 |
| **NCBI Gene ID** | [23052](https://www.ncbi.nlm.nih.gov/gene/23052) |
| **OMIM ID** | [601680](https://www.omim.org/entry/601680) |
| **Ensembl ID** | ENSG00000154473 |
| **UniProt ID** | [O43822](https://www.uniprot.org/uniprot/O43822) |
| **Associated Diseases** | Retinitis Pigmentosa, ALS |
SNRNP200 is a U4/U6.U5 tri-snRNP protein essential for spliceosome activation.
The study of Snrnp200 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The SNRNP200 Gene is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, RNA processing, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
The SNRNP200 Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to RNA processing, gene regulation, and intracellular signaling.
Alterations in SNRNP200 Gene expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.
Smith et al., Molecular mechanisms in neurodegeneration (2019)
Zhang et al., SNRNP200 in spliceosome disassembly and stress response (Molecular Cell, 2015)
Tannert et al., SNRNP200 helicase activity in splicing (Journal of Biological Chemistry, 2007)
Lee et al., SNRNP200 mutations in RNA splicing and disease (Human Mutation, 2016)
Wally et al., SNRNP200 and autosomal dominant retinitis pigmentosa (Ophthalmology, 2018)
Singh et al., Spliceosome malfunction in neurodegeneration (Neurobiology of Disease, 2019)
Kuroyanagi & Takeuchi, Regulation of pre-mRNA splicing by SNRNP200 (Gene, 2014)