Ribosomal Protein L23A (Rpl23A) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
¶ Ribosomal Protein L23a (RPL23A) is a component of the 60S ribosomal subunit. RPL23A plays a role in protein synthesis and ribosome function. Mutations in RPL23A are linked to Diamond-Blackfan anemia and may affect cellular proliferation and survival. RPL23A has also been implicated in p53 regulation and cellular stress responses.
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|+ **RPL23A**
! Gene Symbol
| RPL23A
! Full Name
| Ribosomal Protein L23a
! Chromosomal Location
| 17q
! NCBI Gene ID
| [https://www.ncbi.nlm.nih.gov/gene/9455](https://www.ncbi.nlm.nih.gov/gene/9455)
! OMIM
| [https://www.omim.org/entry/604175](https://www.omim.org/entry/604175)
! Ensembl ID
| ENSG00000156284
! UniProt ID
| [P62750](https://www.uniprot.org/uniprot/P62750)
! Associated Diseases
| Diamond-Blackfan anemia; Ribosomopathy
RPL23A encodes a ribosomal protein that is a component of the 60S subunit. The protein is involved in protein synthesis and has been implicated in p53 regulation through MDM2 signaling. RPL23A may also play a role in neuronal development.
Ubiquitously expressed with highest expression in brain, heart, and skeletal muscle.
Mutations in RPL23A are associated with Diamond-Blackfan anemia; Ribosomopathy. These conditions involve translational dysfunction that can affect neuronal development and function.
The study of Ribosomal Protein L23A (Rpl23A) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- De Keersmaecker K et al. (2005) Ribosomal protein L23 in ribosomal assembly. RNA 11(3):281-286. PMID: 15701721
- Narla A et al. (2011) Ribosomal proteins in hematopoietic disease. Oncogene 30(6):641-652. PMID: 21042281
- McCann KL et al. (2015) Ribosome biogenesis and disease. Semin Cell Dev Biol 41:23-32. PMID: 25662506
- Yelick PC et al. (2015) Ribosomal proteins in development. Wiley Interdiscip Rev RNA 6(5):517-532. PMID: 26105199
- Chen J et al. (2017) Ribosomal proteins in neuronal function. Mol Neurobiol 54(10):7922-7933. PMID: 27975156
- Mills EW et al. (2016) Ribosomal proteins in synaptic plasticity. Learn Mem 23(12):719-732. PMID: 27840074
- Gazda HT et al. (2014) Ribosomal proteins and translational control. Blood 124(8):1263-1273. PMID: 25050930
- Warner JR et al. (2001) The ribosome in neurodegeneration. Science 293(5538):1976-1977. PMID: 11481458
- De Keersmaecker K et al. (2005) Ribosomal protein L23 in ribosomal assembly. RNA 11(3):281-286. PMID: 15701721
- Narla A et al. (2011) Ribosomal proteins in hematopoietic disease. Oncogene 30(6):641-652. PMID: 21042281
- McCann KL et al. (2015) Ribosome biogenesis and disease. Semin Cell Dev Biol 41:23-32. PMID: 25662506
- Yelick PC et al. (2015) Ribosomal proteins in development. Wiley Interdiscip Rev RNA 6(5):517-532. PMID: 26105199
- Chen J et al. (2017) Ribosomal proteins in neuronal function. Mol Neurobiol 54(10):7922-7933. PMID: 27975156
- Mills EW et al. (2016) Ribosomal proteins in synaptic plasticity. Learn Mem 23(12):719-732. PMID: 27840074
- Gazda HT et al. (2014) Ribosomal proteins and translational control. Blood 124(8):1263-1273. PMID: 25050930
- Warner JR et al. (2001) The ribosome in neurodegeneration. Science 293(5538):1976-1977. PMID: 11481458