Il6R Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-gene
| Gene Symbol | IL6R |
| Full Name | Interleukin 6 Receptor |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 3570 |
| OMIM | 147610 |
| Ensembl ID | ENSG00000160712 |
| UniProt | P08887 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Rheumatoid Arthritis, Multiple Sclerosis |
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IL6R encodes the interleukin-6 receptor (IL-6R), a key component of IL-6 signaling. IL-6 is a pleiotropic cytokine with important roles in immune response, inflammation, and acute phase reactions. In the nervous system, IL-6/IL-6R signaling contributes to neuroinflammation, which is a common feature of neurodegenerative diseases.
IL-6R is a type I cytokine receptor that exists in both membrane-bound and soluble forms:
IL-6/IL-6R signaling is elevated in AD:
IL-6/IL-6R contributes to dopaminergic neuron loss:
IL-6 is critical for MS pathogenesis:
IL-6R is a major therapeutic target:
IL6R is expressed on:
The study of Il6R Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.