| Dihydrolipoamide S-Acetyltransferase | |
|---|---|
| Gene Symbol | DLAT |
| Full Name | Dihydrolipoamide S-Acetyltransferase |
| Chromosome | 11q23.1 |
| NCBI Gene ID | 1737 |
| OMIM | 608770 |
| Ensembl ID | ENSG00000150768 |
| UniProt ID | P10515 |
| Associated Diseases | Pyruvate Dehydrogenase Deficiency, Alzheimer's Disease, Diabetes |
DLAT (Dihydrolipoamide S-Acetyltransferase) encodes the E2 component of the pyruvate dehydrogenase complex (PDC). This enzyme is essential for aerobic glucose metabolism and links glycolysis to the TCA cycle by converting pyruvate to acetyl-CoA. DLAT dysfunction has been linked to metabolic disorders, neurodegenerative diseases, and cancer metabolism.
DLAT encodes the E2 component (dihydrolipoamide acetyltransferase) of the pyruvate dehydrogenase complex (PDC). DLAT is the core catalytic component:
DLAT is critical for converting pyruvate to acetyl-CoA and linking glycolysis to the TCA cycle.
DLAT variants cause:
DLAT is expressed in:
High expression in metabolically active tissues.
"1. DLAT structure and PDC assembly - Molecular mechanisms
2. DLAT deficiency - Clinical features
3. DLAT in metabolism and disease - Disease connections