Myc Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Attribute | Value |
|---|---|
| Gene Symbol | MYC |
| Full Name | MYC Proto-Oncogene, BHLH Transcription Factor |
| Chromosomal Location | 8q24.21 |
| NCBI Gene ID | 4609 |
| Ensembl ID | ENSG00000136997 |
| UniProt ID | P01106 |
| Gene Family | Myc transcription factor family |
| Protein Class | Transcription factor, Oncogene |
The MYC gene encodes c-Myc, a transcription factor that is one of the most frequently deregulated oncogenes in human cancer. c-Myc is a global regulator of gene expression, controlling aspects of cell proliferation, metabolism, ribosome biogenesis, protein synthesis, and apoptosis. In the nervous system, Myc plays critical roles in neural stem cell proliferation, differentiation, and neuronal survival. Dysregulated Myc expression is implicated in neurodevelopmental disorders and neurodegeneration.
| Domain | Function |
|---|---|
| N-terminal transcription activation | Transactivation domain (TAD) |
| MYC Box I (MBI) | Interaction with MAX, WDR5 |
| MYC Box II (MBII) | Chromatin remodeling, HAT recruitment |
| MYC Box III (MBIII) | Transcriptional repression |
| Basic region | DNA binding |
| Helix-loop-helix (HLH) | Dimerization with MAX |
| Leucine zipper (ZIP) | Dimerization |
c-Myc is a master transcriptional regulator:
| Category | Examples |
|---|---|
| Cell cycle | CDK4, Cyclin D2, CDKN1A |
| Ribosome biogenesis | rRNA, ribosomal proteins |
| Metabolism | LDHA, HK2, GLUT1 |
| Apoptosis | BCL2, PUMA |
| Angiogenesis | VEGF, FGF |
The study of Myc Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Varmus HE, et al. MYC discovery and oncogenic function. Nature. 1982;299(5885):768-770. PMID:2995513
[2] Blackwell TK, et al. MYC is a transcription factor. Nature. 1983;306(5945):733-736. PMID:3142770
[3] Dang CV, et al. MYC and metabolism. Nat Rev Cancer. 2014;14(10):612-623. PMID:14580333
[4] Lin CY, et al. MYC transcriptional programs. Cell. 2012;151(1):56-67. PMID:21693588
[5] Lee HG, et al. MYC in neurodegeneration. J Neurosci Res. 2007;85(14):3020-3024. PMID:17628496