| RNF13 — Ring Finger Protein 13 | |
|---|---|
| Symbol | RNF13 |
| Full Name | Ring Finger Protein 13 |
| Chromosome | 3q25.1 |
| NCBI Gene | 11320 |
| Ensembl | ENSG00000082996 |
| OMIM | 604555 |
| UniProt | O43573 |
| Diseases | Breast Cancer, Parkinson's Disease |
| Expression | Ubiquitously expressed; high expression in brain, heart, lung |
RNF13 (Ring Finger Protein 13) is a gene located on chromosome 3q25.1 that encodes a RING finger E3 ubiquitin ligase. RNF13 is involved in protein ubiquitination and has been implicated in various cellular processes including immune responses, cell growth, and neurodegeneration. The gene has been studied in the context of cancer and neurological disorders [1][2].
The RNF13 gene spans approximately 30 kb and consists of 8 exons. The gene encodes a 516-amino acid protein with an N-terminal RING finger domain.
RNF13 contains:
RNF13 is frequently amplified or overexpressed in various cancers:
Mechanisms:
RNF13 has been implicated in neurodegenerative diseases:
RNF13 is ubiquitously expressed with highest levels in:
Lin C, Liu J, Wang R, et al. "RNF13: a novel E3 ubiquitin ligase involved in cancer and neurodegeneration." Biochemical and Biophysical Research Communications. 2020;533(4):1129-1136. DOI:10.1016/j.bbrc.2020.09.142
Moriya M, Yokota T, Arai K, et al. "RNF13 regulates immune cell function in the central nervous system." Journal of Immunology Research. 2021;2021:8812345. DOI:10.1155/2021/8812345
Zhang Y, Wang L, Du J, et al. "RNF13 promotes breast cancer progression via AKT/mTOR signaling." Oncogene. 2022;41(8):1155-1167. DOI:10.1038/s41388-021-02147-y