Chst14 Carbohydrate Sulfotransferase 14 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Carbohydrate Sulfotransferase 14 | |
|---|---|
| Gene Symbol | CHST14 |
| Full Name | Carbohydrate Sulfotransferase 14 |
| Chromosome | 19p13.12 |
| NCBI Gene ID | 5657 |
| OMIM | 608429 |
| Ensembl ID | ENSG00000110876 |
| UniProt ID | Q8IWW4 |
| Associated Diseases | Ehlers-Danlos Syndrome, Musculocontractural |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
Carbohydrate sulfotransferase 14 (CHST14/D4ST1) is an enzyme that catalyzes the transfer of sulfate groups to specific positions on chondroitin sulfate and dermatan sulfate glycosaminoglycans. It is essential for proper extracellular matrix assembly[^1].
CHST14 performs functions:
CHST14 mutations cause EDS type IV:
CHST14 is expressed in:
The study of Chst14 Carbohydrate Sulfotransferase 14 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.