Sdhc Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Sdhc Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SDHC
| Symbol | SDHC |
| Full Name | Succinate Dehydrogenase Complex Subunit C |
| Chromosome | 1q23.3 |
| NCBI Gene ID | 6391 |
| OMIM | 605360 |
| Ensembl ID | ENSG00000143252 |
| UniProt ID | O75347 |
| Encoded Protein | SDHC Protein |
| Associated Diseases | Pheochromocytoma, Paraganglioma, Mitochondrial Complex II Deficiency |
The SDHC gene encodes SDHC Protein, a protein involved in various cellular processes relevant to neuronal function and survival. This gene is implicated in the pathogenesis of several neurodegenerative diseases.
| Disease | Inheritance | Key Mutations |
|---|---|---|
| Pheochromocytoma | Various | Pathogenic variants |
| Paraganglioma | Various | Pathogenic variants |
| Mitochondrial Complex II Deficiency | Various | Pathogenic variants |
SDHC is expressed in various brain regions, with notable expression in:
Expression data is available from the Allen Human Brain Atlas.
Sdhc Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Sdhc Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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7.的钱J, Liu Y, Jiang Y. "SDH-related mitochondrial disorders." Journal of Medical Genetics. 2018;55(8):513-520. DOI:10.1136/jmedgenet-2018-105312