The IQCK gene (IQ Motif Containing Kinase) encodes a serine/threonine protein kinase that contains an IQ motif, which typically binds calmodulin in a calcium-dependent manner. IQCK has been implicated in Alzheimer's disease through genome-wide association studies (GWAS). The protein is expressed in brain tissue, particularly in regions affected by Alzheimer's disease pathology.
IQCK is a serine/threonine protein kinase with an IQ motif that may mediate calmodulin binding. While the specific physiological substrates and cellular functions remain incompletely characterized, the IQ motif suggests involvement in calcium-dependent signaling pathways. Calmodulin-regulated kinases play important roles in synaptic plasticity, neurotransmitter release, and calcium homeostasis—processes dysregulated in Alzheimer's disease.
IQCK has been identified as a genetic risk factor for late-onset Alzheimer's disease through GWAS. SNPs in the IQCK locus are associated with increased AD risk. The mechanism may involve alterations in calcium signaling or neuronal homeostasis. IQCK represents a potential therapeutic target requiring further investigation.
IQCK is expressed in brain, with higher expression in cortex and hippocampus. Expression is enriched in neurons. The gene shows moderate expression levels compared to housekeeping genes.