| Symbol | PRKCD |
| Full Name | protein kinase C delta |
| Chromosome | 1p36.11 |
| NCBI Gene ID | 5580 |
| OMIM | 176977 |
| Ensembl ID | ENSG00000163932 |
| UniProt ID | Q05639 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS, Cancer |
Protein kinase C delta (PKCδ) is a novel PKC isoform activated by DAG but calcium-independent. It plays diverse roles in apoptosis, cell cycle regulation, and immune responses. In neurons, PKCδ is involved in oxidative stress-induced apoptosis, excitotoxicity, and neuroinflammation. PKCδ activation contributes to dopaminergic neuron death in Parkinson's disease and motor neuron toxicity in ALS. It is a potential therapeutic target for neurodegenerative diseases.
Widely expressed in various tissues. High expression in brain (especially basal ganglia), hematopoietic cells, endocrine organs. Expressed in neurons, astrocytes, microglia, and oligodendrocytes.
The PRKCD gene is associated with the following neurodegenerative and neurological conditions:
Alzheimer's disease, Parkinson's disease, ALS, Cancer
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.