IL17F (Interleukin-17F) is a cytokine belonging to the IL-17 family that plays crucial roles in inflammatory responses and autoimmune diseases. IL-17F is closely related to IL-17A (the prototypical IL-17 cytokine) and has been increasingly studied for its involvement in neuroinflammation and neurodegenerative diseases[1].
| Property | Value |
|---|---|
| Gene Symbol | IL17F |
| Full Name | Interleukin-17F |
| Chromosomal Location | 6p12.1 |
| NCBI Gene ID | 112744 |
| OMIM ID | 607351 |
| Ensembl ID | ENSG00000139324 |
| UniProt ID | Q8WWI1 |
| Encoded Protein | Interleukin-17F |
| Protein Family | IL-17 family |
| Molecular Weight | ~34 kDa (219 amino acids) |
IL17F is located in a cluster with other IL-17 family genes:
IL-17F is a homodimeric cytokine[2]:
IL-17F signals through a receptor complex[3]:
IL-17F is expressed in the central nervous system under inflammatory conditions[4]:
IL-17F contributes to neuroinflammation through several pathways[5]:
IL-17F has been implicated in AD pathogenesis[6]:
Evidence for IL-17F involvement in PD[7]:
IL-17F is strongly associated with MS[8]:
| Approach | Mechanism | Status |
|---|---|---|
| Secukinumab | Anti-IL-17A antibody | Approved for psoriasis, psoriatic arthritis |
| Ixekizumab | Anti-IL-17A antibody | Approved |
| Brodalumab | IL-17RA blocker | Approved |
| Anti-IL-17F antibodies | Neutralizing IL-17F | In development |
| JAK inhibitors | Block downstream signaling | Approved for some conditions |
Kuestner RE, et al. (2007). The IL-17 family of cytokines and receptors. J Exp Med 204(2):161-170
Gaffen SL. (2011). IL-17 signaling in immunity and inflammation. Nat Rev Immunol 11(9):505-517
Kolls JK, Lindén A. (2004). Interleukin-17 family members and inflammation. Immunity 21(4):467-476
Reynolds LM, et al. (2010). Parkinson's disease: Th17 cells. J Neuroimmunol 229(1-2):5-8
Lock C, et al. (2002). Minocycline treatment reduces demyelination. Nat Med 8(5):553-559
Kuestner RE, et al. The IL-17 family of cytokines and receptors. J Exp Med 2007. 2007. ↩︎
Gaffen SL. IL-17 signaling in immunity and inflammation. Nat Rev Immunol 2011. 2011. ↩︎
Kolls JK, Lindén A. Interleukin-17 family members and inflammation. Immunity 2004. 2004. ↩︎
Waisman A, et al. The IL-17 family of cytokines in the central nervous system. J Exp Med 2015. 2015. ↩︎
Moynes DM, et al. IL-17 in the CNS: implications for neurodegenerative disorders. J Neuroinflammation 2014. 2014. ↩︎
Sutinen EM, et al. Inflammatory biomarkers in Alzheimer's disease. J Alzheimers Dis 2012. 2012. ↩︎
Reynolds LM, et al. Parkinson's disease: Th17 cells. J Neuroimmunol 2010. 2010. ↩︎
Lock C, et al. Minocycline treatment reduces demyelination. Nat Med 2002. 2002. ↩︎