RELA (p65) is a critical transcription factor subunit of the NF-κB signaling pathway, playing essential roles in inflammation, cell survival, and neuronal function. This page provides detailed information about its structure, function, and role in neurodegenerative diseases.
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RELA (also known as p65) encodes the p65 subunit of the NF-κB transcription factor complex. NF-κB is a key regulator of inflammatory responses, cell survival, and immune function. In the brain, RELA-mediated signaling influences neuronal survival, neuroinflammation, and the pathogenesis of Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
The RELA gene encodes the p65 subunit of NF-κB, also known as RELA. This protein is the key transcriptional activator of the NF-κB signaling pathway.
The NF-κB family consists of five members:
RELA is activated by:
RELA/p65 activation in Alzheimer's disease Alzheimer's Disease:
In Parkinson's disease Parkinson's Disease, RELA:
RELA in ALS Amyotrophic Lateral Sclerosis:
RELA interacts with numerous proteins and pathways:
The study of Rela (Nf Κb P65) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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