Camk4 — Calcium Calmodulin Dependent Kinase 4 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this gene. See the content below for detailed information.
| CAMK4 — Calcium/Calmodulin-Dependent Kinase 4 | |
|---|---|
| Symbol | CAMK4 |
| Full Name | Calcium/Calmodulin-Dependent Kinase 4 |
| Chromosome | 5q31.3 |
| NCBI Gene | 814 |
| Ensembl | ENSG00000152495 |
| OMIM | 114080 |
| UniProt | Q16566 |
| Diseases | Alzheimer's Disease, Intellectual Disability, Cancer |
| Expression | Hippocampus, Cerebellum, Testis, T-lymphocytes |
CaMK4 is a calcium/calmodulin-dependent protein kinase involved in transcriptional regulation, synaptic plasticity, and immune function. It activates transcription factors including CREB and regulates gene expression in response to calcium signaling.
The CAMK4 gene encodes Calcium/Calmodulin-Dependent Kinase 4, a serine/threonine protein kinase that is activated by calcium/calmodulin binding. CaMK4 phosphorylates various targets including transcription factors (CREB, ATF1), histone deacetylases (HDAC4, HDAC5), and other kinases. It plays important roles in gene transcription, synaptic plasticity, and immune responses.
Alzheimer's Disease, Intellectual Disability, Cancer — Dysregulation of CaMK4 signaling has been implicated in Alzheimer's disease, where it affects synaptic plasticity and memory formation. Mutations in CAMK4 have been linked to intellectual disability.
CAMK4 is expressed in hippocampus, cerebellum, testis, and T-lymphocytes. In the brain, it is localized primarily in the postsynaptic density and nucleus of neurons.
The study of Camk4 — Calcium Calmodulin Dependent Kinase 4 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.