Kcna6 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNA6 (Potassium Voltage-Gated Channel Subfamily A Member 6) encodes the Kv1.6 subunit, a voltage-gated potassium channel expressed in the nervous system and cardiovascular system. This gene is located on chromosome 12p13.
| Property |
Value |
| Gene Symbol |
KCNA6 |
| Full Name |
Potassium Voltage-Gated Channel Subfamily A Member 6 |
| Chromosomal Location |
12p13.31 |
| NCBI Gene ID |
3747 |
| Ensembl ID |
ENSG00000141401 |
| UniProt ID |
P17658 |
- Neuronal excitability - Regulates action potential repolarization
- Neurotransmitter release - Modulates presynaptic calcium entry
- Hormone secretion - Regulates endocrine cell excitability
- Epilepsy - Associated with seizure susceptibility
- Neurodevelopmental disorders - Channel expression alterations
- Hippocampus
- Cortex
- Cerebellum
- Peripheral nervous system
- Stocker M, Kupper J. (1998). "Expression and function of neuronal Kv1 channels." Ann N Y Acad Sci. PMID:9678567
The study of Kcna6 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Stocker M, Kupper J. (1998). "Expression and function of neuronal Kv1 channels." Ann N Y Acad Sci. 868:124-134. PMID:9678567
- Chandy KG, et al. (1990). "A family of three human potassium channel genes expressed in myelinated nerves." J Biol Chem. 265(29):17693-17700. PMID:1697893
- Gutman GA, et al. (2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels." Pharmacol Rev. 57(4):473-508. PMID:16382104
- Misonou H, Trimmer JS (2004). "Determinants of voltage-gated potassium channel distribution in neurons." J Neurobiol. 58(2):169-188. PMID:14704951