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| Symbol | EPHB4 |
| Full Name | Eph Receptor B4 |
| Chromosome | 5q22.1 |
| NCBI Gene | 2050 |
| OMIM | 600010 |
| Ensembl | ENSG00000196411 |
| UniProt | P54760 |
| Associated Diseases | Vascular development (relevant to neurovascular unit) |
EPHB4 (Eph Receptor B4) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-B ligands, EPHB4 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHB4 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease.
EPHB4 is a receptor tyrosine kinase for ephrin-B2. It primarily regulates vascular development and is relevant to blood-brain barrier function in neurodegeneration.
Expressed in vasculature and certain brain regions.