PLP2 encodes a proteolipid protein involved in oligodendrocyte function and myelin maintenance. This page provides information about its structure, function, and role in neurological disorders.
PLP2 (Proteolipid Protein 2) encodes a minor proteolipid protein expressed in the central and peripheral nervous systems. While the related gene PLP1 is crucial for CNS myelin formation, PLP2 has distinct functions in oligodendrocyte biology and may play roles in demyelinating diseases and neuronal protection.
| Property | Value |
|---|---|
| Gene Symbol | PLP2 |
| Full Name | Proteolipid Protein 2 |
| Chromosomal Location | Xp11.23 |
| NCBI Gene ID | 5352 |
| Ensembl ID | ENSG00000101955 |
| UniProt ID | P60228 |
| OMIM | 300102 |
| Property | Value |
|---|---|
| Protein Name | Proteolipid Protein 2 (PLP2) |
| Molecular Weight | ~20 kDa (176 amino acids) |
| Subcellular Localization | Plasma membrane, endoplasmic reticulum |
| Protein Family | PLP family |
| Approach | Status | Description |
|---|---|---|
| Remyelination therapies | Research | Enhancing PLP2 expression |
| Biomarker development | Research | Disease monitoring |
The study of Plp2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.