Tert Gene (Telomerase) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value |
|---|---|
| Gene Symbol | TERT |
| Full Name | Telomerase Reverse Transcriptase |
| Chromosomal Location | 5p15.33 |
| NCBI Gene ID | 7015 |
| OMIM ID | 187270 |
| Ensembl ID | ENSG00000164362 |
| UniProt ID | O14774 |
| Encoded Protein | Telomerase reverse transcriptase |
| Associated Diseases | Aplastic anemia, IPF, neurodegeneration |
TERT is a gene involved in various cellular processes. The encoded protein plays important roles in metabolism, cellular signaling, and disease pathogenesis.
TERT encodes the catalytic subunit of telomerase, which maintains telomere length by adding telomeric repeats to chromosome ends. Telomerase is essential for cellular immortality.
Key functions include:
TERT mutations cause aplastic anemia through:
TERT mutations are associated with familial IPF.
TERT dysregulation contributes to neurodegeneration through:
TERT is expressed in:
The study of Tert Gene (Telomerase) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.