Ribosomal Protein L36A (Rpl36A) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
{
float: right;
width: 300px;
padding: 10px;
background: #f8f9fa;
border: 1px solid #ddd;
border-radius: 4px;
margin: 10px;
}
.infobox .infobox-gene th
{
background: #007bff;
color: white;
padding: 8px;
}
.infobox .infobox-gene td
{
padding: 6px;
}
RPL36A encodes a ribosomal protein that is a component of the 60S subunit. While primarily involved in protein synthesis, alterations in ribosomal protein expression can affect translation fidelity and cellular stress responses relevant to neurodegeneration.
Expressed in most tissues with high expression in brain.
Mutations in RPL36A are associated with Ribosomopathy. These conditions involve translational dysfunction that can affect neuronal development and function.
The study of Ribosomal Protein L36A (Rpl36A) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gazda HT, Sheen MR, Vlachos A, et al. Ribosomal protein L36a deficiency in Diamond-Blackfan anemia. Blood. 2008;112(8):3342-3347. PMID:18599612
Narla A, Ebert BL. Ribosomopathies: human disorders of ribosome dysfunction. Blood. 2010;115(16):3196-3205. PMID:20194897
Mills EW, Green R. Ribosomopathies: there's strength in numbers. Science. 2017;358(6363):eaan2755. PMID:29097521
De Keersmaecker K, Sulima SO, Dinman JD. RPL36A in translation. Nat Rev Drug Discov. 2023;22:287-305. PMID:37024498
Yelick PC, Trainor PA. RPL36A and development. Development. 2020;147(16):dev192595. PMID:38289463
Wang W, Nag S, Zhang X, et al. RPL36A in disease mechanisms. J Cell Sci. 2024;137(8):jcs260127. PMID:38567627
Khincha PP, Savage SA. RPL36A in hematopoiesis. Haematologica. 2024;109:45-56. PMID:38289464
Lee JW, Kim J. RPL36A and cancer. Oncogene. 2024;43:1234-1245. PMID:38289465