Gene Symbol: PIK3R6
Full Name: Phosphoinositide-3-Kinase Regulatory Subunit 6
Chromosomal Location: 17p13.1
NCBI Gene ID: 27137
OMIM: 607270
Ensembl ID: ENSG00000110676
UniProt ID: Q9NRA8
Associated Diseases: Parkinson's Disease, Neurodegeneration
Pik3R6 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Pik3R6 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PIK3R6 encodes the p101/p84 regulatory subunit of class I phosphoinositide 3-kinases (PI3Ks). While primarily studied in immune cells, emerging evidence suggests a role in neuronal function and neurodegeneration.
- PI3K regulation: Regulatory subunit for PI3K catalytic subunits
- Signal transduction: Mediates intracellular signaling pathways
- Cell survival: PI3K/Akt pathway promotes cell survival
- Cytoskeletal organization: Involved in membrane dynamics
The PIK3R6 protein contains multiple domains:
- SH2 domains: Phosphotyrosine binding
- SH3 domains: Proline-rich region binding
- iSH2 domain: Inter-Src homology 2 domain for catalytic subunit interaction
- GWAS associations with PD risk
- Potential role in neuronal survival pathways
- May affect autophagy regulation
Pik3R6 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Pik3R6 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Satake W, et al. "Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease." Nat Genet. 2009;41(12):1303-1307. DOI:10.1038/ng.485
- International Parkinson's Disease Genomics Consortium. "Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies." Lancet. 2011;377(9766):641-649.
- Zhou Q, et al. "Class IA PI3K in neuronal development and neurological disorders." Prog Lipid Res. 2018;70:50-66. DOI:10.1016/j.plipres.2018.02.001
- Cantley LC. "The phosphoinositide 3-kinase pathway." Science. 2002;296(5573):1655-1657. DOI:10.1126/science.296.5573.1655
- Franke TF. "PI3K/Akt: Getting it right matters." Oncogene. 2008;27(50):6473-6488. DOI:10.1038/onc.2008.313
- Shepherd C, et al. "PI3K/Akt signaling in neuronal function and survival." Cell Mol Neurobiol. 2015;35(4):479-486. DOI:10.1007/s10571-014-0122-1
- Ghiglieri V, et al. "PI3K in neuroprotection and brain disorders." Curr Neuropharmacol. 2019;17(1):8-17. DOI:10.2174/1570159X15666170504102153
- Duda P, et al. "Targeting PI3K/Akt signaling in the nervous system for neurodegenerative disease therapy." J Neurochem. 2021;158(4):799-812. DOI:10.1111/jnc.15328