| VKORC1L1 — Vitamin K Epoxide Reductase Complex Subunit 1-Like 1 | |
|---|---|
| Symbol | VKORC1L1 |
| Full Name | Vitamin K Epoxide Reductase Complex Subunit 1-Like 1 |
| Chromosome | 7q11.22 |
| NCBI Gene | 89439 |
| Ensembl | ENSG00000137868 |
| UniProt | Q8N4U2 |
| Diseases | Alzheimer's Disease |
| Expression | Brain, Liver, Lung, Heart |
VKORC1L1 (Vitamin K Epoxide Reductase Complex Subunit 1-Like 1) is a gene located on chromosome 7q11.22 that encodes a vitamin K epoxide reductase enzyme. While structurally similar to the canonical VKORC1 gene involved in warfarin sensitivity, VKORC1L1 has distinct tissue distribution and physiological functions[^ORC1L1]. VK1 has been implicated in Alzheimer's disease risk through genome-wide association studies (GWAS), highlighting the potential role of vitamin K metabolism in neurodegenerative processes[1][2].
| Property | Value |
|---|---|
| Location | 7q11.22 |
| Protein | VKORC1L1 (~373 aa) |
| Primary function | Vitamin K metabolism |
| Tissue expression | Brain, Liver, Lung, Heart |
VKORC1L1 plays a crucial role in the vitamin K cycle:
VKORC1L1 variants have been associated with AD risk in GWAS studies[1:1][2:1]:
VKORC1L1 interacts with several key proteins and pathways:
The study of Vkorc1L1 Gene Vitamin K Epoxide Reductase Complex Subunit 1 Like 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013;45(12):1452-1458. [PMID:24162737](https://pubmed.ncbi.nlm.nih.gov/24162737/) ↩︎ ↩︎
Karch CM, Goate AM. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry. 2015;77(1):43-51. [PMID:25195381](https://pubmed.ncbi.nlm.nih.gov/25195381/) ↩︎ ↩︎
Tie JK, Stafford AR, Zhou Y, et al. Functional characterization of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1). J Thromb Haemost. 2015;13(7):1264-1273. [PMID:25903649](https://pubmed.ncbi.nlm.nih.gov/25903649/) ↩︎
Bellettato CM, Scarpa M. Possible involvement of gas6/TAM system in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2018;61(4):1457-1469. [PMID:29332053](https://pubmed.ncbi.nlm.nih.gov/29332053/) ↩︎