| Symbol | SMAD7 |
| Full Name | SMAD family member 7 |
| Chromosome | 18q21.1 |
| NCBI Gene ID | 4093 |
| OMIM | 602932 |
| Ensembl ID | ENSG00000101680 |
| UniProt ID | O15117 |
| Associated Diseases | Colorectal cancer, Fibrosis, IBD |
SMAD7 is an inhibitory SMAD that blocks TGF-β signaling by binding to TGF-β type I receptor and preventing R-SMAD phosphorylation. It is a key negative regulator of fibrosis, inflammation, and epithelial-mesenchymal transition. SMAD7 is a therapeutic target for inflammatory bowel disease and fibrosis. In the nervous system, SMAD7 modulates neuroinflammation, glial scar formation, and neuronal survival. It may play protective roles in neurodegeneration.
Widely expressed with high levels in brain, heart, lung, and kidney. In brain, expressed in neurons, astrocytes, and microglia. Important for regulating neuroinflammatory responses.
The SMAD7 gene is associated with the following neurodegenerative and neurological conditions:
Colorectal cancer, Fibrosis, IBD
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.