Pomt2 Protein O Mannosyltransferase 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Protein O-Mannosyltransferase 2 | |
|---|---|
| Gene Symbol | POMT2 |
| Full Name | Protein O-Mannosyltransferase 2 |
| Chromosome | 14q24.3 |
| NCBI Gene ID | 29954 |
| OMIM | 607352 |
| Ensembl ID | ENSG00000044090 |
| UniProt ID | Q8N5L2 |
| Associated Diseases | Muscular Dystrophy, Limb-Girdle; Walker-Warburg Syndrome |
This page provides comprehensive information about the subject's role in neurodegenerative diseases. The subject participates in various molecular pathways and cellular processes relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
Protein O-mannosyltransferase 2 (POMT2) works together with POMT1 to catalyze the first step of O-mannosylation of proteins. It forms a functional complex with POMT1 in the endoplasmic reticulum[^1].
POMT2 performs functions:
POMT2 mutations cause WWS:
POMT2 can cause LGMD:
POMT2 is expressed in:
The study of Pomt2 Protein O Mannosyltransferase 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.