MYPN (Myopalladin) is a sarcomeric protein located at the Z-disc that plays a crucial role in maintaining sarcomere structure and signaling. It interacts with nebulin, alpha-actinin, and CARP. Mutations in MYPN cause cardiomyopathy and nemaline myopathy.
| Property | Value |
|---|---|
| Gene Symbol | MYPN |
| Gene Name | Myopalladin |
| Chromosomal Location | 10q21.3 |
| NCBI Gene ID | 84665 |
| OMIM | 608002 |
| UniProt | Q8WWI5 |
MYPN (Myopalladin) is a sarcomeric protein located at the Z-disc that plays a crucial role in maintaining sarcomere structure and signaling. It interacts with nebulin, alpha-actinin, and CARP. Mutations in MYPN cause cardiomyopathy and nemaline myopathy.
The MYPN gene is associated with the following neurodegenerative and related diseases:
MYPN expression and its relevance to brain function is under active investigation.