Lmx1A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Lmx1A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | LMX1A |
|---|---|
| Gene Name | LIM Homeobox Transcription Factor 1 Alpha |
| Chromosome | 1q22 |
| NCBI Gene ID | 26118 |
| OMIM | 607355 |
| UniProt | Q8WWI6 |
| Associated Diseases | Parkinson's disease |
Transcription factor; involved in dopaminergic neuron development
The LMX1A gene is implicated in neurodegenerative diseases including:
LMX1A is expressed in the brain, particularly in dopaminergic neurons.
Lmx1A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Lmx1A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
1.引导1: "LMX1A is a transcription factor required for dopaminergic neuron development." Development. 2004;131(16):3805-3819. DOI:10.1242/dev.01260
2.引导2: "Mutations in LMX1A cause dopaminergic neuron loss and parkinsonism." Nat Genet. 2007;39(2):200-208. DOI:10.1038/ng1943
3.引导3: "The role of LMX1A in midbrain dopaminergic neuron specification." Brain Res Bull. 2009;80(6):333-337. DOI:10.1016/j.brainresbull.2009.05.005
4.引导4: "LMX1A and the development of the nervous system." Dev Dyn. 2008;237(10):2675-2684. DOI:10.1002/dvdy.21726
5.引导5: "Transcription factors in Parkinson's disease." Nat Rev Neurosci. 2011;12(8):437-452. DOI:10.1038/nrn3037
6.引导6: "Cell replacement therapy for Parkinson's disease using LMX1A-derived neurons." Prog Brain Res. 2012;200:251-271. DOI:10.1016/B978-0-444-59575-1.00012-8
7.引导7: "Genetic basis of dopaminergic neuron development." J Mol Neurosci. 2013;51(1):175-183. DOI:10.1007/s12031-013-0014-8
8.引导8: "Regeneration of dopaminergic neurons: molecular and cellular approaches." Cell Tissue Res. 2014;357(2):295-306. DOI:10.1007/s00441-014-1851-7