| Gene Symbol | ALEX1 |
|---|---|
| Full Name | ARM Repeat Expressed 1 |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 10523 |
| OMIM | 607369 |
| Ensembl ID | ENSG00000141934 |
| UniProt ID | Q9Y5L8 |
| Associated Diseases | Neurodegeneration, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia |
ALEX1 (ARM Repeat Expressed 1), also known as KIAA0408 or ARMH1 (Armadillo Repeat Containing 1), is a gene encoding a protein with armadillo repeats that is expressed in various tissues, including the brain. The protein localizes to the cytoplasm and is implicated in protein-protein interactions.
ALEX1 contains multiple armadillo repeats, which are known to mediate protein-protein interactions. The protein is thought to be involved in:
ALEX1 expression is reduced in certain neurodegenerative diseases. Studies have shown:
ALEX1 shows widespread but moderate expression:
Subcellular localization is primarily cytoplasmic.
Last updated: 2026-03-08