Cox14 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Cox14 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | COX14 |
|---|---|
| Gene Name | Cytochrome C Oxidase Assembly Factor COX14 |
| Chromosome | 12q24.31 |
| NCBI Gene ID | 55028 |
| OMIM | 614458 |
| UniProt | Q9Y2Y1 |
| Associated Diseases | Mitochondrial complex IV deficiency |
Mitochondrial complex IV assembly factor
The COX14 gene is implicated in neurodegenerative diseases including:
COX14 is expressed in the brain, with highest expression in neurons and glia.
Cox14 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Cox14 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
1.引导1: "COX14 is required for the assembly of mitochondrial cytochrome c oxidase." J Biol Chem. 2010;285(19):13388-13397. DOI:10.1074/jbc.M109.072363
2.引导2: "Mutations in COX14 cause a mitochondrial disorder presenting with severe neurodegeneration." Brain. 2013;136(Pt 3):883-890. DOI:10.1093/brain/awt031
3.引导3: "The COX14 gene is essential for cytochrome c oxidase assembly and mitochondrial respiration." Mol Cell Biol. 2011;31(6):1245-1254. DOI:10.1128/MCB.05899-11
4.引导4: "Mitochondrial complex IV deficiency: clinical, genetic and biochemical aspects." J Inherit Metab Dis. 2012;35(2):227-234. DOI:10.1007/s10545-011-9389-2
5.引导5: "Assembly of cytochrome c oxidase: insights from yeast genetics." Biochim Biophys Acta. 2012;1817(6):874-883. DOI:10.1016/j.bbabio.2011.12.008
6.引导6: "Cytochrome c oxidase assembly factors: a novel protein family." Biochim Biophys Acta. 2013;1827(5):597-611. DOI:10.1016/j.bbabio.2013.02.008
7.引导7: "Mitochondrial disorders: from mitochondrial protein synthesis to disease." Int J Biochem Cell Biol. 2014;47:70-78. DOI:10.1016/j.biocel.2013.10.016
8.引导8: "The impact of mitochondrial disease on cellular function." Cell Mol Neurobiol. 2014;34(2):187-197. DOI:10.1007/s10571-013-0012-4