| SHH — Sonic Hedgehog | |
|---|---|
| Symbol | SHH |
| Full Name | Sonic Hedgehog |
| Chromosome | 7q36.3 |
| NCBI Gene | 6469 |
| Ensembl | ENSG00000164690 |
| OMIM | 600725 |
| UniProt | Q15465 |
| Diseases | Parkinson's Disease, Holoprosencephaly, Basal Cell Carcinoma |
| Expression | Substantia nigra, Cerebellum, Developing brain |
Shh — Sonic Hedgehog is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
SHH (Sonic Hedgehog) encodes a secreted signaling molecule that plays a fundamental role in embryonic development, cell differentiation, and tissue patterning. SHH is one of three mammalian hedgehog proteins and is crucial for nervous system development.
SHH is a secreted glycoprotein that signals through the Patched (PTCH1) receptor to activate Smoothened (SMO), triggering downstream GLI transcription factor activation. Key functions include:
SHH signaling is critically involved in Parkinson's disease:
Dysregulated SHH signaling implicated in oligodendrocyte pathology.
SHH pathway modulators are being explored for:
The study of Shh — Sonic Hedgehog has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.